Utilizing single‐cell RNA sequencing (scRNA‐seq) of 30 LUAD samples, genome‐wide association studies (GWAS) involving 29,863 patients and 55,586 controls, and clinical data from 220 LUAD patients, we identified N‐Myc downstream‐regulated gene 1 (NDRG1) as a key pathogenic gene in LUAD, strongly associated with tumor progression and poor prognosis. The gene discussed is NDRG1; the disease is neoplasm.