OTX2 and pituitary stalk interruption syndrome: Genetic testing is recommended in syndromic cases or familial hypopituitarism to look for mutations in SOX3, OTX2, HESX1, and LHX4, which have been associated with PSIS. Management of PSIS includes timely replacement of deficient hormones along with regular follow-up so as to detect the emergence of newer hormone deficiencies.