It requires the presence of raised inflammatory markers (C reactive protein: CRP and/or serum amyloid A: SAA), and at least two of six typical signs and/or symptoms of CAPS: urticarial-like rash, cold/stress triggered episodes, sensorineural hearing loss, musculoskeletal symptoms (arthralgia, arthritis/myalgia), chronic aseptic meningitis and/or skeletal abnormalities (epiphyseal overgrowth/frontal bossing). This evidence concerns the gene CRP and arthritic joint disease.