The mitogen-activated protein kinase (MAPK) pathway is intricately linked to glycolysis; the v-raf murine sarcoma viral oncogene homolog B (BRAF)/MAPK pathway is initiated by growth factors, cytokines or hormones binding to a membrane-bound receptor tyrosine kinase (RTK), which induces an interaction between activated RAS and the RAF domain, modulating the shift from oxidative phosphorylation (OXPHOS) to glycolysis in melanoma cells (12, 13). Here, WNK2 is linked to melanoma.