Vascular endothelial growth factor C (VEGF-C), which is a lymphangiogenic factor secreted by melanoma cells and tumor-associated macrophages (TAMs), is upregulated in the A375P melanoma cell line under acidic conditions, and the expression of VEGF-C depends on the nuclear factor kappa-B (NF-κB) activity (53). This evidence concerns the gene NFKB1 and melanoma.