Meanwhile, KEGG pathway analysis highlighted significant enrichment in key pathways such as IL-17 signaling, AGE-RAGE signaling, and cytokine-cytokine receptor interaction (Figure 3C).In summary, this analysis identified 13 genes with significant expression changes in periodontitis, closely linked to oxidative stress, offering insights into the molecular mechanisms of periodontitis pathogenesis. The gene discussed is RENBP; the disease is periodontitis.