Dietary EPA supplementation increased the levels of endometrial EPA- and EPA-containing phospholipids, suppressed inflammation and pregnancy loss, and improved placental function in Srebf1-/- endometritis, which suggests that dysregulation of PUFA (EPA in particular) metabolism due to Srebf1 deficiency contributes to prolonged endometrial inflammation and miscarriage. Here, SREBF1 is linked to spontaneous abortion.