Multivariate Cox analysis confirmed hypoalbuminemia (HR [95% CI: 2.051-6.408]) and the expression of VSIG4 (HR [95% CI: 1.201-5.067]) as independent risk factors and rituximab use as a protective factor of OS (HR [95% CI: 0.223-0.718]) (Table 2). The gene discussed is VSIG4; the disease is Hypoalbuminemia.