CD4 and neoplasm: VSIG4, a surface marker specifically expressed in macrophages and certain tumor cells, showed positive correlations with M1 and M2 macrophages, CD8+ T cells and activated CD4+ memory T cells, γδT cells, but negative correlations with resting CD4+ memory T cells, follicular T helper cells, regulatory T cells, monocytes and M0 macrophages in the TME (Figure 2E).