In this mechanism, the increased levels of IFN-γ secreted from activated CD8+ T cells could suppress SLC3A2 and SLC7A11 (two important subunits of the glutamate-cystine antiporter system xc-) and restrain tumor cell cystine uptake, thus leading to lipid peroxidation and ferroptosis in tumor cells (57). Here, CD8A is linked to neoplasm.