In our study, we compared BD samples to HC and found that nine factors associated with the IL-17 pathway (Jun, Fosb, Fosl1, TNFAIP3, NFKBIA, CXCL2, CXCL8 IL-6 and IL-17) were upregulated in the transcriptome sequencing of bipolar disorder, and some of the upregulated genes were further validated by qPCR. The gene discussed is FOSB; the disease is bipolar disorder.