It has also been found that severe acute respiratory syndrome (SARS)-coronavirus (CoV) infection induces p38 MAPK-mediated Ser380 phosphorylation of p90RSK but not through Erk1/2-induced Thr573 phosphorylation in kidney epithelial cells, indicating a role of epithelial intracellular p90RSK signaling in virus-induced kidney damage (Mizutani et al., 2006). The gene discussed is RPS6KA1; the disease is Nephropathy.