Although this study provides preliminary insights into the role of EPHX2 in ccRCC, future research still needs to make continuous efforts in expanding the sample size, optimizing the grouping strategy, enhancing external validation, and improving the evaluation system, with the aim of more accurately revealing the specific mechanism of EPHX2 in the occurrence and development of ccRCC. The gene discussed is EPHX2; the disease is nonpapillary renal cell carcinoma.