Although some studies suggest that SGLT2i may elevate low-density lipoprotein cholesterol(LDL-C)levels, this mechanism is likely associated with reduced expression and activity of LDL receptors (54).However, there is controversy regarding changes in LDL-C levels; the small, dense LDL-C subtype is more likely to contribute to atherosclerosis, while the large, buoyant LDL-C subtype has a relatively weaker impact. Here, COG2 is linked to atherosclerosis.