Regulates OPA1 protein expression to modulate mitochondrial function, affecting the proliferation and migration of vascular endothelial cells. It also acts on the NF-κB signaling pathway, inhibiting the transmission of inflammatory signals to mitochondria, reducing oxidative stress, and stabilizing intracellular homeostasis to improve cardiovascular diseases and atherosclerosis. This evidence concerns the gene NFKB1 and atherosclerosis.