Baseline characteristics were compared between patients with DPN and patients without DPN, significant statistical differences were found between the groups in terms of age, gender, smoking status, hypertension, NE, LYM, NLR, Hb, uric acid, HbA1c, TC, SCR, Albumin, LDH, and diabetes duration (P < 0.05). The gene discussed is GSTM1; the disease is diabetes mellitus.