After adjusting for age, race, gender, marital status, education level, WC, BMI, insulin, albumin, hypertension status, DM status, smoking status, drinking status, hyperlipidemia status, as BUN increased, the risk of HUA increased significantly in both men (OR: 1.19, 95% Cl:1.16~1.23) and women (OR:1.32, 95% Cl:1.32 (1.28~1.37)(all p < 0.001). This evidence concerns the gene ALB and hypertensive disorder.