In this study, we used data from NHANES, which, after weighted analysis, found that BUN was positively associated with HUA in U.S. adults (OR,1.24; 95%CI: 1.20-1.28) after adjusting for age, race, sex, marital status, education level, BMI, insulin, albumin, hypertensive status, DM status, smoking status, drinking status, and hyperlipidemia status. The gene discussed is INS; the disease is hyperlipidemia.