Immunohistochemically, neurothekeomas stain positive for several markers, including S-100A6, NKI/C3, neuron-specific enolase, CD10, MITF, CD68, and α-smooth muscle actin, whereas being negative for S-100 protein, GFAP, Melan-A, and CD3.6 Here, ENO2 is linked to neurothekeoma.