Panoramic radiographs and intraoral radiographs are recommended for thorough assessment and management of dental anomalies, and to monitor the risk factors for osteonecrosis of the jaw, particularly in the setting of bisphosphonate or denosumab treatment.8 Whether GNAS mutations can occur in the cells related to tooth development, such as ameloblasts or odontoblasts, and how this might affect the dental phenotypes in FD, are still largely unknown. This evidence concerns the gene GNAS and Fabry disease.