The study highlights the pivotal role of the NLRP3-ASC inflammasome—comprising the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) and ASC (CARD-containing apoptotic speck-like protein)—in amyloid-β-induced microgliopathy and amyloid pathology. Here, PYCARD is linked to amyloidosis.