The second-ranked article, “Aggregated Tau Activates NLRP3-ASC Inflammasome Exacerbating Exogenously Seeded and Non-Exogenously Seeded Tau Pathology In Vivo,” by Ilie-Cosmin Stancu, published in *Acta Neuropathologica*, explores the interplay between amyloid plaques, neurofibrillary tangles, and neuroinflammation in Alzheimer’s disease. This evidence concerns the gene NLRP3 and early-onset autosomal dominant Alzheimer disease.