Cluster 1 (red) contains 54 keywords, including neuroinflammation, nlrp3 inflammasome, microglia, mouse model, nf kappa b, innate immunity, aging, astrocyte, blood–brain barrier, cognitive deficits, cytokine, genome-wide association, mitophagy, multiple sclerosis, nitric oxide, t cell, tau pathology, toll-like receptor. This evidence concerns the gene MAPT and Cognitive impairment.