In addition, vitamin C enhances TET2-mediated 5hmC modification at GPX4 promoter regions, counteracting sepsis-induced DNA hypermethylation (mean methylation level decreased by 37.2%, p = 0.009), thereby preserving glutathione peroxidase 4 (GPX4) activity and significantly reducing renal lipid peroxidation markers such as 4-HNE by 54% compared to controls (23). This evidence concerns the gene GPX4 and Sepsis.