Regarding patients with PCOS, curcumin had a non-significant effect on improving testosterone (T) level (WMD: 0.128; 95%CI: 0.383, 0.127; I2 = 98.6%), dehydroepiandrosterone-sulfate (WMD: 8.239; 95% CI: 30.260, 13.781; I2 = 62.3%), luteinizing hormone (LH) (WMD: 0.003; 95%CI: 0.007, 0.000; I2 = 0.0%) and follicle-stimulating hormone (FSH) (WMD: 0.002; 95%CI: 0.024, 0.029; I2 = 0.0%) compared to placebo (Shen et al., 2022). The gene discussed is BRD2; the disease is polycystic ovary syndrome.