Tetrahydrocurcumin (THP) induces the polarization of M1 macrophages to M2 by inhibiting the TLR4/NF-κB/NLRP3 signaling pathway, thereby alleviating acute lung injury caused by limb ischemia-reperfusion in rats (Li et al., 2023). The gene discussed is NLRP3; the disease is limb ischemia.