MAFLD is widely recognized as a complex condition with multifactorial etiology, involving various contributors such as lipid metabolism disorders, endoplasmic reticulum (ER) stress, inflammatory activation, insulin resistance (IR), leptin resistance, oxidative stress, and dysbiosis of the gut microbiota (Rives et al., 2020; Wang et al., 2021; Wei et al., 2016). This evidence concerns the gene LEP and Insulin resistance.