THBS1 and intrahepatic cholangiocarcinoma: THBS1 and THBS2 are reported to be associated with ECM and angiogenesis inhibition processes in intrahepatic cholangiocarcinoma,28 and THBS1-related intercellular communication plays a role in liver fibrosis29 and contributes to immunosuppression and metastasis of colorectal cancer30; THBS2+ cancer-associated fibroblasts (CAFs) can promote the invasiveness of early lung adenocarcinoma.31