Either GFP-Renca Ctrl or IL34-OE cells were orthotopically implanted for primary tumor generation (i.e., PT_Ctrl and PT_IL34-OE) or injected into the tail vein to study the TME of lung metastasis (i.e., IVLM_Ctrl and IVLM_IL34-OE). Here, IL34 is linked to neoplasm.