LacCer synthesis is catalyzed by beta-1,4-galactosyltransferase 6 (B4GALT6), whose expression is controlled by NF-κB and upregulated in astrocytes in experimental autoimmune encephalomyelitis (EAE) in non-obese diabetic mice (Mayo et al., 2014). Here, B4GALT6 is linked to experimental autoimmune encephalomyelitis.