Notably, adverse life events was associated with significantly increased DNA methylation in women who did not develop PPD.12 This finding was replicated in an independent cohort; moreover, DNA methylation in the region was negatively correlated with oestradiol (E2) ratios, and the interaction between E2 and OXTR methylation was positively associated with the ratio of allopregnanolone (ALLO) to progesterone (PROG). This evidence concerns the gene OXTR and progressive pseudorheumatoid arthropathy of childhood.