IL6 and palmoplantar pustulosis: Their findings suggest a balanced interplay between pro-inflammatory and anti-inflammatory responses, indicating that the immune system adapts during the postpartum period to maintain equilibrium and prevent excessive inflammation.98 Similarly, Sathyanarayanan et al99 also showed elevated IL-6 and uniquely elevated IL-8/CXCL-8 in the PPP group, suggesting a specific role of IL-8/CXCL-8 in PPP development.