KCNQ1 plays an important role in the secretion of K+ into the endolymph to maintain the EP.[402, 403] Mutations in the KCNQ1 gene cause recessive HL associated with Jervell and Lange–Nielsen syndrome.[404] Common mutations in Kcnq1 are missense mutations that result in amino acid replacements. The gene discussed is KCNQ1; the disease is Hodgkins lymphoma.