Comprehensive analyses, including cytometry by time ‐of‐ flight (CyTOF), in vitro co‐culture assays, transgenic mouse models, and azoxymethane (AOM)/dextran sodium sulfate (DSS)‐induced CRC models, demonstrate that VTN enhances CRC proliferation, metastasis, and resistance to therapy. Here, VTN is linked to colorectal carcinoma.