SLC6A8 and cancer: SLC6A8 is an emerging oncogenic factor, with studies reporting its upregulation in various malignant tumors.[53, 54, 55] Acting as a creatine transporter, SLC6A8 contributes to cancer progression by modulating the intracellular concentrations of creatine, phosphocreatine, and ATP, thereby influencing cellular energy dynamics and metabolic reprogramming in tumor cells.[56] Kurth et al.