VTN and colorectal carcinoma: Vitronectin (VTN) is a glycoprotein extensively distributed in the extracellular matrix and plasma, predominantly originating from the liver, with platelets, megakaryocytes, and monocytes/macrophages contributing to minor secretions.[22] This study is the first to identify that VTN can also be secreted by CAFs in CRC, with the expression in CAFs being significantly higher than that in NFs.