PLIN1 and obesity due to melanocortin 4 receptor deficiency: This aligns with other studies demonstrating that perilipin A integrity is influenced by activation factors like PMA, stimulating signaling pathways that result in the phosphorylation of perilipins, leading to their degradation and lipid release.[69, 72] Additionally, obesity‐related inflammatory mediators like TNFα have been shown to reduce perilipin expression in ACs.[73]