A large cohort study has shown that increased CXCL12 levels correlate with risk of myocardial infarction and death in CKD patients,[59] while IL‐6 is associated with CKD patient mortality,[60] and IL‐18 has been shown to be predictive of cardiovascular mortality.[61] Furthermore, we find that ECM density modulates the overall levels of these factors in response to IS treatment (Figure S8, Supporting Information). The gene discussed is IL18; the disease is chronic kidney disease.