INS and type 1 diabetes mellitus: The islet‐specific self‐reactive CD4+ and CD8+ T cells have been observed in peripheral blood circulation, pancreatic lymph nodes, and inflamed pancreatic islets.[41] A diverse array of autoreactive T cells along with NK cells and macrophages, are triggered and oriented toward mistakenly targeting pancreatic β cells as exogenous agents, resulting in their dysfunction and destruction, impaired insulin secretion and disrupted glucose homeostasis eventually contributing to the development and progression of T1D.[42]