Besides, the typical function of DDAH1 is to regulate intracellular NO concentration by modulating ADMA levels.[11] Furthermore, NO concentrations are linked to poor survival and the activation of tumor‐related pathways in various cancers, including breast, colon, and gastric cancers.[] However, our findings showed that altering intracellular NO concentration, either by increasing or decreasing it, did not significantly affect the activation of the EGFR‐JAK2‐STAT3 pathway in NPC cells. The gene discussed is JAK2; the disease is nasopharyngeal carcinoma.