Of note, the identification of both the UMOD locus and FGF5 in relation to hypertension and CKD using local correlation as implemented in LAVA, backed up in both cases by coloc as being attributable to a shared causal variant, establishes the potential utility of this method to identify potential shared mechanisms of disease; interestingly, both UMOD and FGF5 are currently being explored as therapeutic targets for these conditions. The gene discussed is FGF5; the disease is chronic kidney disease.