AKT1 and cancer: Furthermore, it has been known for a long time that inositol 1,3,4,5,6‐pentakisphosphate (Ins(1,3,4,5,6)P5) isomer interacts with avian hemoglobins (Bartlett, 1980; Isaacks & Harkness, 1980; Riera et al., 1991) and more recently, this inositol has been described as having a role in mammalian signaling pathways, for example, in promoting apoptosis in cancer cells through the PI3K/protein kinase B (AKT) pathway (Piccolo et al., 2004).