SRF and cardiac hypertrophy: The expression of Myh14, a marker of isoproterenol‐mediated hypertrophy (Wang et al., 2016), and the transcription factor SRF, a known mediator of cardiac hypertrophy, was significantly increased in Iso‐treated cardiomyocytes as well as in the cardiomyocytes of old animals (Figure 4g,h).