GSK3B may play a role in neuroinflammation [45], neuronal apoptosis, and accumulation of phosphorylated tau in AD [46], while KCNIP3 may play a functional role in the neurobiology of Alzheimer's disease by being part of these gene interaction networks commonly associated with neurodegenerative processes [47]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.