Most interestingly in mice STIM2 gene has been shown to be essential component of CD4T and CD8T-dependent immune response against viral infection [14].The analysis of direction of methylation level changes at these CpG sites (Fig. 1I) showed that methylation at CpG site associated with SKAP1 gene was higher than in blood from healthy donors at all stages of infection, and the methylation levels at CpG site annotated to STIM2 increased most significantly with the infection progression. Here, STIM2 is linked to infection.