TAP2 and Autoimmunity: Majority of these methylation changes were annotated to the genes with established function in immune system including: TAP2 which mediates translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHC I) molecules, TRIM2 which is a protein involved in innate immunity against different DNA and RNA viruses or PLCG1 associated previously with immune dysregulation, autoimmunity, and autoinflammation (source GeneCards).