Majority of these methylation changes were annotated to the genes with established function in immune system including: TAP2 which mediates translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHC I) molecules, TRIM2 which is a protein involved in innate immunity against different DNA and RNA viruses or PLCG1 associated previously with immune dysregulation, autoimmunity, and autoinflammation (source GeneCards). This evidence concerns the gene PLCG1 and Autoimmunity.