Only in the hepatocellular carcinoma cells (HepG2), the co-transfection of sgRNA-KDM4A with dCas9-VP64 increased the KDM4A gene expression by 2.2-fold (p = 0.025) compared to cells co-transfected with dCas9-NED (Supplementary Fig. 2H). Here, KDM4A is linked to hepatocellular carcinoma.