KDM4A and cancer: Unlike HEK293T cells, where the downregulation of KDM4A did not impact cell growth (Supplementary Fig. 3C), both HCT116 and MCF7 cancer cells exhibited reduced cell proliferation following the decrease in KDM4A gene expression induced by CRISPRoff plus sgRNA-KDM4A compared to the controls (Fig. 1B).