Here, we examine kidney function in relation to plasma-based ATN biomarkers β-amyloid (Aβ), phosphorylated tau 181 (p-Tau-181), neurofilament light chain (NfL) – indicative of amyloidosis, tauopathy, and non-specific neurodegeneration, respectively – in a large and representative sample of Hispanic/Latino individuals, the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA). The gene discussed is NEFL; the disease is tauopathy.