In the model adjusted for age, sex, background, APOE, BMI, HbA1c, systolic and diastolic blood pressure (M1), having CKD was associated with lower Aβ42/40, and elevated p-Tau181, NfL, and GFAP (b[CI 95%]Aβ42/40 =-0.003[-0.005; -0.002]; b[CI 95%]p−Tau181 =0.774[0.587; 0.960], b[CI 95%]NfL = 10.307[8.475; 12.139], b[CI 95%]GFAP = 29.202[20.512; 37.892]; ps < 0.001). Here, APOE is linked to chronic kidney disease.