By applying a combination of in silico target prediction, integrative analysis of pan-cancer DUSP2 mRNA expression with microRNA and MAPK phosphorylation data, and literature search microRNAs were identified and validated in vitro for their interaction with the 3’UTR of DUSP2 in a DLBCL cell line model. Here, DUSP2 is linked to diffuse large B-cell lymphoma.