The deletion of ABCA1 and ABCG1 in macrophages accelerates the development of atherosclerosis in LDL receptor-knockout mice, underscoring the pivotal role of cholesterol efflux mediated by ABCA1 and ABCG1 in preventing atherosclerosis (Ouimet et al. 2019). The gene discussed is LDLR; the disease is atherosclerosis.