AEG-1 leads to the secretion of many inflammatory mediators like tumour necrosis factor-α, necrosis factor-κB complex and increasing levels of Toll-like receptor 4 (Wang and Seki 2018). The progression of diabetes involves an interplay between metabolism and immunity causing the release of various types of immune cells (Bhargava and Lee 2012). The gene discussed is TLR4; the disease is diabetes mellitus.