For simplicity, the positive correlation parameters (CK-1, EMA, and AFP) were placed in the numerator, while the negative correlation parameter (Albumin) was placed in the denominator to formulate the following function: Simplified HCC-Check: [CK-1 (μg/ml) × Log AFP (ng/ml) × EMA (μg/ml) /Albumin (g/dL)]. The gene discussed is KRT1; the disease is hepatocellular carcinoma.