For example, despite CRP level being significantly elevated in ME/CFS cases (TE analysis: adjusted P = 2.8 × 10−9; both sexes), only 4.8% of female and 2.5% of male ME/CFS cases (versus 2.2% and 1.8% controls, respectively) had CRP levels over 10 mg/L, a moderate elevation that can indicate systemic inflammation in autoimmune disease. Here, CRP is linked to autoimmune disease.