Copine-6 is associated with conditions such as epilepsy and depression, with elevated expression in the temporal lobes of patients with temporal lobe epilepsy and reduced expression in the hippocampus of rat models of depression (Han et al, 2018; Zavala-Tecuapetla et al, 2020; Zhu et al, 2016). This evidence concerns the gene CPNE6 and depressive symptom measurement.