GRAMD1B and Anxiety: Among these is rs59808825 (GRAMD1B [nearest gene]), for which the main effect of the C allele on LDLC was positive (β = 5.0, SE = 2.1 mg/dL) but an inverse interaction effect with ANXT (βInteraction = −22.9, SE = 4.2 mg/dL), so that the total effect of the C allele among those reporting anxiety symptoms was negative (P2df = 8.8 × 10−9; Fig. 2B).