Forkhead box protein O1 (FOXO1) is another key effector in the induction of necroptosis in NAFLD, while serpina3c suppresses necroptosis by downregulating the β-catenin/FOXO1/TLR4 signaling axis, thereby inhibiting NAFLD progression [146]. The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatotic liver disease.