NSUN2 and microcephaly: In several other families with NSUN2 mutations, the Dubowitz-like syndrome, which presents with exhibits mental retardation, growth retardation, microcephaly features, and a mutation in a conserved residue (p. Gly679Arg) by a pure missense variant of NSUN2, causes spasticity, ataxic gait, and developmental delayed dysmorphism in the child (Khan et al., 2012; Martinez et al., 2012).