A recent longitudinal study showed that a healthy lifestyle, including nutritious diet, regular physical exercise, positive social interactions, active cognitive engagement, and abstaining from alcohol and smoking, was associated with slower memory decline in older adults, even among those carrying the apolipoprotein E (APOE) ε4 allele, which is linked to a higher risk of AD (Jia et al., 2023). The gene discussed is APOE; the disease is Alzheimer disease.