MAPT and Alzheimer disease: DBS in AD mice significantly reduced Aβ plaques in the frontal cortex and subiculum region, as well as the cellular level of Aβ42 in CA1. It also decreased P-tau in the cortex and T-tau in both the hippocampus and cortex, promoted neurogenesis in the dentate gyrus, and thereby improved hippocampus-dependent spatial memory deficits, restoring them to levels comparable to wild-type mice.