SCNN1B and hypertensive disorder: Studies in South Africa have identified specific mutations in the SCNN1B gene, which encodes the β-subunit of ENaC, associated with Liddle syndrome.42 The p.Arg563Gln (R563Q) mutation was found in 5.9% of hypertensive Black South Africans compared with 1.7% in normotensive individuals, suggesting a strong association with hypertension in this group.48 This mutation was, however, notably absent in West African populations.